• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The combined product for the treatment of pain of the invention using drugs, vitamins and minerals in small doses for the relief of pain in general, for sale without prescription, which is applied by the digestive tract and consists of a combination of analgesics, painkillers, anti-inflammatory, antithrombotic, antipyretic, vitamins and minerals following: a) Acetylsalicylic acid (aspirin) and/or acetaminophen as main components, both in reduced doses, b) Combined with at least three of vitamins B1, B3, B6, B12 , C, D, folic acid or caffeine, c) Adding at least one of the following elements; phosphorus, calcium, selenium, magnesium chloride, vitamins E, vitamin H (biotin) or beta-carotene (provitamin A) and d) optionally adding small amounts of an anti-inflammatory drug of the NSAID group (NSAID) such as ibuprofen, diclofenac or metamizole, in amounts between the fifteenth and tenth of the maximum daily dose. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2685301A1
    申请号:ES201700536
    申请日:2017-03-31
    公开日:2018-10-08
    发明作者:Manuel MUÑOZ SÁIZ
    申请人:Manuel MUÑOZ SÁIZ；
    IPC主号:
    专利说明:

    image 1
    image2
    image3 DESCRIPTION
    Combined product for pain treatment. Field of the Invention
    In treatments of fever, pain in general and for the prevention of heart attacks, sold in pharmacies and parapharmacies. State of the art
    There are many products against fever and pain, most of which are difficult to replace and counterproductive because they have side effects, especially those that cause bleeding from the digestive system. In general, all products have drawbacks depending on the dose used, the problem arises when, due to lack of optimal medications, the alternatives with high side effects must be used and therefore, with a certain degree of exposure to them. With the present invention, a product is obtained whose composition predominates vitamins and minerals, almost harmless elements, and drugs in small doses that reduce the inconveniences of current drugs without having to do without them. Object of the invention
    Provide a broad spectrum medication against pain, inflammations, etc. with minimal side effects, curative and cardiovascular protector.
    Use reduced or minimal doses especially those that create the most important problems, such as bleeding.
    By diversifying and therefore reducing the quantities used, a less invasive product is achieved without having to give up part of its individual characteristics or properties.
    Avoid the use of anti-inflammatory or analgesic drugs individually due to contraindications to typical doses of use.
    Use a product that can be used more or more frequently. Description of the invention
    The combined product for the treatment of pain of the invention using drugs, vitamins and minerals in small doses for pain relief in general, over-the-counter, which is applied digestively and consists of a combination of pain relievers, pain relievers, Relaxing, anti-inflammatory, antithrombotic, antipyretic, following vitamins and minerals: a) As main components acetylsalicylic acid (aspirin) and / or paracetamol, both in reduced doses, b) Combined with at least three of vitamins B1, B3, B6, B12 , C, D, folic acid or caffeine, c) Adding at least one of the following elements: phosphorus, calcium, selenium, magnesium chloride, vitamins E, vitamin H (biotin) or beta-carotene (provitamin A) and d) Optionally adding small amounts of an NSAID group anti-inflammatory drug (NSAID) such as ibuprofen, diclofenac or metamizol, in amounts between the fifteenth and tenth of the maximum daily dose.
    As excipients can be used: a) As binders: Starches, sugars and celluloses such as hydroxypropyl cellulose or lactose, sorbitol or maltitol, b) For filling: Vegetable cellulose, dibasic calcium phosphate, c) As lubricants: talc or silica, and fats steroids, d) For
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    coating a layer of cellulose, synthetic polymers or other polysaccharides and e) Disintegrants, sweeteners, flavorings and dyes.
    The product can also be manufactured in tablets of two or more layers. The innermost zone or core may be acetylsalicylic acid (aspirin), the next layer of ibuprofen or diclofenac and the outermost layer of one or more of the remaining mixed products. Acetylsalicylic acid and ibuprofen or diclofenac can be used together in the nucleus and the rest of the components in the outer layer. Being separated and having a hard and gastro-resistant outer shell that retards its dissolution.
    The amounts per pill: tablet, capsule, sachet, etc., of acetylsalicylic acid and diclofenac, ibuprofen or metamizol if one of these last three is used, should be applied in minimum or medium doses but limited depending on tolerance, allergies or status and age of the patient to whom it applies; the minimum ones can be for long-term treatments and the highest ones for circumstantial use.
    The product can be presented in sachets, dragees or capsules. The amounts used by these are typical between approximately 500 or 600 mg.
    To avoid repetitions in the document, mentioning pill will refer to tablets, dragees, tablets, capsules and sachets. Characteristics and quantities of the elements used
    Aspirin is used as an analgesic, anti-inflammatory, antipyretic, antithrombotic and prevention of heart attacks and certain cancers. These last two properties are obtained even at small doses.
    Ibuprofen, a derivative of propionic acid, is an anti-inflammatory, analgesic and somewhat antipyretic, which does not irritate both the stomach and aspirin and is not anticoagulant. It can be used in minimal amounts when associated with aspirin.
    Diclofenac, a derivative of acetic acid, whose therapeutic action is to relieve pain and inflammation, although this medication does not cure. It can be used in minimal amounts when associated with aspirin.
    Metamizole, a derivative of pyrazolone, analgesic, antipyretic, antispasmodic and anti-inflammatory.
    Paracetamol (DCI) or acetaminophen, a paraminophenol, is a drug with analgesic properties, but no anti-inflammatory properties. In doses less than 1 gram or if it is not used for a long time, it does not damage the gastric mucosa, the kidneys, nor has an effect on blood clotting. However, Paracetamol makes the liver work a lot and in very high doses or in combination with alcohol it can damage it.
    Thiamine (vitamin B1) exerts a physiological antineuritic and detoxifying action on the nervous system and is involved in the synthesis of the neurotransmitter acetylcholine. Its lack produces indeterminate pains.
    Vitamin B3 useful in headache, muscle weakness and treatment of indeterminate pain.
    Pyridoxine (vitamin B6), intervenes as a coenzyme in various reactions of the metabolism of vitamins and amino acids. In its pyridoxal phosphate form it participates in various
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    Enzymatic reactions that lead to the formation of pain-related neurotransmitters such as serotonin and gamma-aminobutyric acid (GABA), in addition to other neurotransmitters such as dopamine, norepinephrine and histamine. Useful in lack of muscle tone, arm and leg cramps.
    Hydroxocobalamin or cyanocobalamin (vitamin B12), has antalgic properties because it participates in the formation of myelin sheaths by regulating the electrical impulse in axons, it also has the property of enhancing the analgesic effect of NSAIDs. It is useful for tiredness, depression, mouth and tongue aches, nerve inflammation and spinal cord degeneration.
    Ascorbic acid, (vitamin C) is useful for swollen joints and pain.
    Calciferol, (vitamin D), is useful in muscle weakness, bone pain and fractures. It is a good antidepressant and anticancer.
    Caffeine has muscle relaxant, vasoconstrictor and pericraneal properties, being useful for headaches.
    Magnesium chloride is a natural relaxant and tranquilizer.
    Alfatocoferol, (vitamin E), is useful as an anti-inflammatory, and in menstrual cramps and cramps.
    Biotin, (vitamin H), is useful in muscle aches and depression.
    Beta carotene, (provitamin A), is useful in muscle aches.
    Phosphorus prevents pain, body weakness, excess fatigue, weak bones and teeth and prevents lack of joint flexibility.
    Calcium is useful in bone formation and protection.
    Selenium is indicated in acute pain.
    The approximate amount or dose used per tablet of each of the different elements is: Acetylsalicylic acid 100-200 mg. Paracetamol 150-300 mg., Thiamine Hydrochloride, (Vitamin Bl), 30-60 mg., Niacin (Vitamin B3), 20-40 mg, Pyridoxine (Vitamin B6), 30-60 mg., Cyanocobalamin (Vitamin B12) , 200 to 1000 mcg. (Or pg), Ascorbic acid (Vitamin C), 75-125 mg., Calciferol (Vitamin D), 150-200 IU, Folic acid 75-125 mcg. (or pg), Caffeine between 20-40 mg., 250 mg magnesium chloride, Alfatocoferol (Vitamin E), 200-400 IU, Biotin (Vitamin H), 20-40 mcg. (or pg), Beta-carotene 15 mg., Phosphorus 200 mg., Calcium 300 mg. and Selenium 50 mcg (or pg). Doses of the optional elements Ibuprofen 150-240 mg. (daily maximum 2400 mg), Diclofenac 10-15 mg. (daily maximum 150 mg), Metamizol 8-12 mg, (daily maximum 120 mg) approximately between the fifteenth and tenth of the maximum daily dose, but these amounts may be slightly reduced.
    The specified doses should not be limiting, allowing minor modifications.
    For some treatments some vitamins may be increased in the composition of the proposed product. As an example, vitamin C can be increased up to 1 gr per day.
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    权利要求:
    Claims (25)
    [1]
    image 1
    one.  Combined product for the treatment of pain using drugs, vitamins and minerals in small doses for pain relief in general, without prescription, which is applied by digestive route and consists of a combination of analgesics, soothing, relaxing, anti-inflammatory, antithrombotic, antipyretic, vitamins and minerals below: a) as main components acetylsalicylic acid (aspirin) and / or paracetamol, both in reduced doses, b) combined with at least three of vitamins B1, B3, B6, B12, C, D , folic acid or caffeine and c) adding at least one of the following elements: phosphorus, calcium, selenium, magnesium chloride, vitamins E, vitamin H (biotin) or beta-carotene (provitamin A).
    [2]
    2.  Product according to claim 1, characterized in that an anti-inflammatory of the NSAID group (NSAID) is added: ibuprofen, diclofenac or metamizol in amounts between the fifteenth and tenth of the maximum daily doses.
    [3]
    3.  Product according to claim 1, characterized by using as excipients: a) As binders: Starches, sugars and celluloses, such as hydroxypropyl cellulose or lactose, sorbitol or maltitol, b) For filling: Vegetable cellulose, dibasic calcium phosphate, c) As lubricants: talc
    or silica, and steroid fats, d) For coating a layer of cellulose, synthetic polymers or other polysaccharides and also e) Disintegrants, sweeteners, flavorings and dyes.
    [4]
    Four.  Product according to claim 1, characterized in that it is manufactured in tablets of two or more layers, the innermost zone or core is of acetylsalicylic acid (aspirin), the next layer of ibuprofen or diclofenac or metamizol and the outermost of the remaining mixed products , being separated and having a hard and gastro-resistant outer covering that retards its dissolution.
    [5]
    5.  Product according to claim 1, characterized in that it is manufactured in tablets of two or more layers, the innermost zone or core of acetylsalicylic acid and ibuprofen, diclofenac or metamizol and the outside of the remaining products mixed, being separated and having a hard outer shell and gastro-resistant.
    [6]
    6.  Product according to claim 1, characterized in that the amount or dose used per tablet of acetylsalicylic acid is between 100 and 200 mg.
    [7]
    7.  Product according to claim 1 and 2, characterized in that the amount used per Ibuprofen tablet is between 150 and 240 mg.
    [8]
    8.  Product according to claim 1 and 2, characterized in that the amount used per Diclofenac tablet is between 10 and 15 mg and that of Metamizol between 8 and 12 mg.
    [9]
    9.  Product according to claim 1, characterized in that the amount used per Paracetamol tablet is between 150 and 300 mg.
    [10]
    10.  Product according to claim 1, characterized in that the amount used per tablet of Thiamine Hydrochloride, Vitamin Bl, is between 30 and 60 mg.
    [11]
    eleven.  Product according to claim 1, characterized in that the amount used per Niacin tablet, Vitamin B3, is between 20 and 40 mg.
    [12]
    12.  Product according to claim 1, characterized in that the amount used per pyridoxine tablet, Vitamin B6, is between 30 and 60 mg.
    [13]
    13.  Product according to claim 1, characterized in that the amount used per tablet of Cyanocobalamin, Vitamin B12, is between 200 and 1000 mcg (or pg).
    [14]
    14.  Product according to claim 1, characterized in that the amount used per tablet of ascorbic acid, Vitamin C, is between 75 and 125 mg.
    [15]
    fifteen.  Product according to claim 1, characterized in that the amount used per tablet of Calciferol, Vitamin D, is between 150 and 200 IU.
    [16]
    16.  Product according to claim 1, characterized in that the amount used per tablet of folic acid is between 75 and 125 mcg (or pg).
    [17]
    17.  Product according to claim 1, characterized in that the amount used per caffeine tablet is between 20 and 40 mg.
    [18]
    18.  Product according to claim 1, characterized in that the amount used per magnesium chloride tablet is 250 mg.
    [19]
    19.  Product according to claim 1, characterized in that the amount used per pill of Alfatocoferol, Vitamin E, is between 200 and 400 IU.
    [20]
    twenty.  Product according to claim 1, characterized in that the amount used per tablet of Vitamin H (Biotin) is between 20 and 40 mcg (or pg).
    [21]
    twenty-one.  Product according to claim 1, characterized in that the amount used per Beta-carotene tablet is 15 mg.
    [22]
    22  Product according to claim 1, characterized in that the amount used per Phosphorus tablet is 200 mg.
    [23]
    2. 3.  Product according to claim 1, characterized in that the amount used per tablet of Calcium is 300 mg.
    [24]
    24.  Product according to claim 1, characterized in that the amount used per Selenium tablet is 50 mcg (or pg).
    [25]
    25.  Product according to claim 1, characterized in that it is presented in sachets, dragees or capsules.
    5
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    同族专利:
    公开号 | 公开日
    ES2685301B1|2019-08-21|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    GB2225236A|1988-11-29|1990-05-30|Brian Burnand Rolph|Medicine for the treatment and prevention of stress and nervous disorders|
    WO1995007082A1|1993-09-10|1995-03-16|EGIS Gyógyszergyár Rt.|A combination tablet comprising acetylsalicylic acid and a process for the preparation thereof|
    RU2101014C1|1995-09-07|1998-01-10|Акционерное общество "Курский комбинат лекарственных средств"|Analgetic, antiinflammatory, antipyretic medicinal agent and a method of its preparing|
    US5948443A|1996-02-23|1999-09-07|Medical Doctor's Research Institute, Inc.|Acetylsalicylic acid and micronutrient supplementation for nutritional losses and coronary heart disease|
    US5770215A|1997-01-06|1998-06-23|Moshyedi; Emil Payman|Multivitamin/vascular occlusion inhibiting composition|
    US6440983B1|2000-12-21|2002-08-27|Mary Theresa Frank-Kollman|Compositions and methods for relieving headache symptoms in aspirin-sensitive headache sufferers|
    US20050260283A1|2004-05-20|2005-11-24|Medical Futures Inc.|Composition for prevention and treatment of colon adenomas|
    法律状态:
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    优先权:
    申请号 | 申请日 | 专利标题
    ES201700536A|ES2685301B1|2017-03-31|2017-03-31|Combined product for pain treatment|ES201700536A| ES2685301B1|2017-03-31|2017-03-31|Combined product for pain treatment|
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